Osteoporosis medication and oral health.
In the Theoretical Thursdays Blog, it is our objective to bring dental hygienists current peer-reviewed articles that you may find of interest. While we cannot post the article, we will provide the citation, describe it to you and tell you where on the internet you can find it if it is an open access article, email it to you for personal use if allowed by the publisher, or if a librarian is not available we will help you locate the article. Please contact us with the journal title for assistance.
Migliorati, C. A., Mattos, K., & Palazzolo, M. J. (2010). How patients' lack of knowledge about oral bisphosphonates can interfere with medical and dental care. Journal of the American Dental Association (1939), 141(5), 562-566.
The above study examined 73 patients of whom 74% were prescribed oral biphosphonates for osteoporosis, 22% for osteopenia, and 1% for breast cancer. These patients were interviewed to determine their knowledge of why they were taking the medication: 82% reported they were not informed by their physician of the side effects such as osteonecrosis of the jaw and 80% reported they did not know the duration of their treatment. The implications of this study are to ensure dental health professionals obtain a thorough medical history prior to planning dental treatment, secure patients’ signed informed consent prior to invasive procedures, and not recommend patients discontinue medical therapy without consulting their physician.
The following fact sheet is available for dental patients: Osteoporosis medications and oral health. (2009). Journal of the American Dental Association, 140, 812.
For discussion of the risks of osteonecrosis of the jaw associated with taking oral phosphonates see the article below:
Edwards, B. J., Hellstein, J. W., Jacobsen, P. L., Kaltman, S., Mariotti, A., Migliorati, C. A., & American Dental Association Council on Scientific Affairs Expert Panel on Bisphosphonate-Associated Osteonecrosis of the Jaw. (2008). Updated recommendations for managing the care of patients receiving oral bisphosphonate therapy: An advisory statement from the american dental association council on scientific affairs. Journal of the American Dental Association (1939), 139(12), 1674-1677.
Please note that there is discussion that osteonecrosis of the jaw may not be associated with a history of taking biphosphonates. See the article below:
Kyrgidis, A., & Toulis, K.A. (2011). Denusumab-related osteonecrosis of the jaws. Osteoporos International, 22(1), 369-70. DOI 10.1007/s00198-010-1177-6
Investigating the absorption of 2% lidocaine and 4% articaine with and without epinephrine using the inferior alveolar nerve block
In the Theoretical Thursdays Blog it our objective to bring dental hygienists current peer-reviewed articles that you may find of interest. While we cannot post the article we will provide the citation, describe it to you and tell you where on the internet you can find it if it is an open access article, email it to you for personal use if allowed by the publisher, or if a librarian is not available we will help you locate the article. Please contact us with the journal title for assistance.
January 11, 2012
Ay, S., Kucuk, D., Gumus, C., & Kara, I. (2011). Distribution and absorption of local anesthetics in inferior alveolar nerve block: Evaluation by magnetic resonance imaging. Journal of Oral Maxillofacial Surgery, 69, 2722-2739.
Doi: 10.1016/j/joms.2011.02.087
This article compares four groups of healthy volunteers investigating the absorption of 2% lidocaine and 4% articaine with and without epinephrine using the inferior alveolar nerve block. The interesting findings of this Turkish research is that all four types of anesthetic were absorbed at 120 minutes after injection and there were no between group differences in absorption and distribution on magnetic resonance imaging. The intensity of all types of anesthetic were highest post-injection and there were no differences in onset time between the groups. The groups with epinephrine had longer duration of numbness than the non-epinephrine groups, but there were no significant differences between articaine and lidocaine with epinephrine. Lidocaine without epinephrine differed significantly form the other groups in terms of duration.
